局部使用前列腺素滴眼剂对角膜厚度及眼压的影响

doi:10. 13281/j. cnki. issn.1004-4469. 2016. 01. 005

眼科

局部使用前列腺素滴眼剂对角膜厚度及眼压的影响

朱小敏李海军朱晓燕贺翔鸽谢琳

400042重庆市，第三军医大学大坪医院野战外科研究所眼科重庆市眼科学重点实验室

收稿日期:2015-10-09 出版日期:2016-01-25 发布日期:2016-01-28
通讯作者: 谢琳，Email：xielin_66@163.com

Effects of topical application of prostaglandin eye drops on corneal thickness and intraocular pressure

ZHU Xiao-min, LI Hai-jun, ZHU Xiao-yan, HE Xiang-ge, XIE Lin.

Department of Ophthalmology, Daping Hospital and Research Institute of Surgery, the Third Military Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing 400042, China

Received:2015-10-09 Online:2016-01-25 Published:2016-01-28
Contact: XIE Lin，Email：xielin_66@163.com

摘要/Abstract

摘要：

目的探讨局部使用前列腺素滴眼剂对角膜厚度及眼压的影响。设计前瞻性比较性病例系列。研究对象 119例原发性开角型青光眼患者。方法随机分0.004%曲伏前列素滴眼剂组（Tra组）（71眼）和0.15%酒石酸溴莫尼定滴眼剂组（Bri组）（48眼）。利用Pentacam 眼前段分析仪检查用药3、6个月后两组患者的中央角膜厚度（CCT）、顶端角膜厚度（ApexCT）、最薄角膜厚度（TCT）以及距离TCT 2、4、6、8 μm处的角膜厚度（CT2、CT4、CT6、CT8）变化，以及Goldmann压平眼压计校正眼压（c-IOP）值的变化。主要指标中央和周边角膜厚度、矫正眼压。结果用药前及用药6个月后Tra组CCT变化在（555.35±36.51）~（549.68±36.43） μm（P均<0.05）、ApexCT变化在（553.80±36.42）~（549.14±36.41） μm（P均<0.05）、TCT变化在（552.11±36.29）~（546.15±35.87） μm（P均<0.05）以及CT2、CT4、CT6、CT8较用药前均有相似变薄趋势（P均<0.05）。其中用药3个月CCT较用药前平均变薄（4.63±0.62） μm，6个月时平均变薄（5.67±0.64）μm。用药前与用药3、6个月的c-IOP差异均无统计学意义。Bri组用药3、6个月后角膜厚度及c-IOP差异均无统计学意义（P均>0.05）。结论局部使用前列腺素滴眼剂是导致角膜厚度变薄的潜在危险因素，而眼压矫正值无明显影响。（眼科，2016，25： 18-22）

关键词: , 原发性开角型青光眼, 角膜厚度, 眼压

Abstract:

Objective To observe the effect of topical using of prostaglandin eye drops on the thickness of the cornea and intraocular pressure. Design Prospective comparable case-control study. Participants One hundred nineteen patients with primary open angle glaucoma. Methods Patients were randomly divided into two groups, 71 eyes in 0.004% travoprost eye drops group (Tra group) and 48 eyes in 0.15% brimonidine tartrate eye drops group (Bri group). Central corneal thickness(CCT), apex corneal thickness (Apex CT), thinnest corneal thickness(TCT) and every 2 μm distant from TCT point were assessed by Pentacam Analyzer and intraocular pressure (IOP) by Goldmann applanation tonometer was corrected at the 3 and 6 months follow up. Main Outcome Measures Central and peripheral corneal thickness; corrected intraocular pressure. Results At the last follow up, the CCT from 555.35±36.51 μm to 549.68±36.43 μm (P<0.05), Apex CT from 553.80±36.42 μm to 549.14±36.41 μm (P<0.05), TCT from 552.11±36.29 μm to 546.15±35.87 μm (P<0.05) and similar to corneal thickness from TCT 2 μm, 4 μm and 6 μm, 8 μm (CT2 and CT4, CT6 and CT8) in Tra group (P<0.05). In the 3 months, CCT was getting thinner for average 4.63±0.62 μm after 3 months’ treatment and average 5.67±0.64 μm after 6 months’ treatment. There were no significant differences in corrected intraocular pressure(c-IOP) at the baseline and the follow up (P>0.05). And no significant statistical differences was found between corneal thickness and c-IOP in Bri-group (P>0.05). Conclusion Topical use of prostaglandin eye drops is one of potential risk factors to make corneal thinner, despite of no effect on c-IOP. (Ophthalmol CHN, 2016, 25: 18-22)

Key words: primary open angle glaucoma, corneal thickness, intraocular pressure

朱小敏李海军朱晓燕贺翔鸽谢琳. 局部使用前列腺素滴眼剂对角膜厚度及眼压的影响[J]. 眼科, doi: 10. 13281/j. cnki. issn.1004-4469. 2016. 01. 005.

ZHU Xiao-min, LI Hai-jun, ZHU Xiao-yan, HE Xiang-ge, XIE Lin. . Effects of topical application of prostaglandin eye drops on corneal thickness and intraocular pressure [J]. Ophthalmology in China, doi: 10. 13281/j. cnki. issn.1004-4469. 2016. 01. 005.

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局部使用前列腺素滴眼剂对角膜厚度及眼压的影响

Effects of topical application of prostaglandin eye drops on corneal thickness and intraocular pressure

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